Modern drug discovery includes screening hit identification, medicinal chemistry, and affinity, selectivity (to reduce the potential for side effects), efficacy, metabolic stability (to extend half-life), and oral. Includes optimization of those hits to determine for increased bioavailability
Screening methods based on phenotypic drug detection have been used to discover new natural products mainly of terrestrial origin. Examples of exploring marine natural products are provided. The Future Trends section provides a comprehensive overview of recent advancements that will benefit the pharmaceutical industry
Molecular biology and genomics.
Multiple proteins are manipulated.
Poly pharmacology is a branch of pharmacology
Techniques in phytochemistry
Compound binding affinity and ADMET characteristics
Assay biochemical
Pharmacological and physiochemical characteristics