Drug discovery and Screening

Once a drug is created it undergoes lots of stages. The method is to subject new chemical entities to a set of screening tests designed to detect different types of biological activity. These include in Vitro screens and in Vivo screens. Clinical testing in humans involves four phases. Phase 1 is the measurement of pharm logical activity. Phase 2 is the pilot studies in small group of patients to confirm that the drug works on target condition. Phase 3 is formal clinical trials in a large number of patients to determine the incidence of unwanted effects. Phase 4 is post marketing surveillance to establish efficacy and toxicity in general use.
  • Chemical diversity
  • Plant-derived
  • Microbial metabolites
  • Mass spectrometry

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